Mandrake (official), Mandragora officinalis. Mandrake is a plant of antiquity and many strange superstitions. Traditionally used to relieve pain and promote sleep. Known to cause strange delirium and madness. It was one of the original herbs found in a witch’s garden in Europe. Note: Very toxic. Mandrake is native to southern Europe and the Mediterranean. Prefers well composted, well drained soils in an open, sunny position. Produces small bell shaped flowers in spring. Drought and frost tender. A perennial plant growing to 0.1m x 0.15m.